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Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells

BACKGROUND: Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. Epigenetic events, such as promoter hypermethylation and chromatin histone deacetylation, silence the expression of tumor suppressor genes...

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Bibliografiske detaljer
Main Authors: Hurtubise, Annie, Bernstein, Mark L, Momparler, Richard L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600626/
https://ncbi.nlm.nih.gov/pubmed/19014694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-8-16
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