Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells

BACKGROUND: Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. Epigenetic events, such as promoter hypermethylation and chromatin histone deacetylation, silence the expression of tumor suppressor genes...

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Detaylı Bibliyografya
Asıl Yazarlar: Hurtubise, Annie, Bernstein, Mark L, Momparler, Richard L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2008
Konular:
Primary Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600626/
https://ncbi.nlm.nih.gov/pubmed/19014694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-8-16
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