Preclinical evaluation of the antineoplastic action of 5-aza-2'-deoxycytidine and different histone deacetylase inhibitors on human Ewing's sarcoma cells

BACKGROUND: Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. Epigenetic events, such as promoter hypermethylation and chromatin histone deacetylation, silence the expression of tumor suppressor genes...

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Hlavní autoři: Hurtubise, Annie, Bernstein, Mark L, Momparler, Richard L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2008
Témata:
Primary Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600626/
https://ncbi.nlm.nih.gov/pubmed/19014694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-8-16
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