CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors

CK2, a protein serine/threonine kinase, promotes cell proliferation and suppresses cell death. This essential-for-survival signal demonstrates elevated expression and activity in all cancers examined, and is considered an attractive target for cancer therapy. Here, we present data on the efficacy of...

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Pubblicato in:Oncotarget
Autori principali: Ahmed, Khalil, Kren, Betsy T., Abedin, Md. Joynal, Vogel, Rachel I., Shaughnessy, Daniel P., Nacusi, Lucas, Korman, Vicci L., Li, Yingming, Dehm, Scott M., Zimmerman, Cheryl L., Niehans, Gloria A., Unger, Gretchen M., Trembley, Janeen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308691/
https://ncbi.nlm.nih.gov/pubmed/27557516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11442
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