CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors

CK2, a protein serine/threonine kinase, promotes cell proliferation and suppresses cell death. This essential-for-survival signal demonstrates elevated expression and activity in all cancers examined, and is considered an attractive target for cancer therapy. Here, we present data on the efficacy of...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Ahmed, Khalil, Kren, Betsy T., Abedin, Md. Joynal, Vogel, Rachel I., Shaughnessy, Daniel P., Nacusi, Lucas, Korman, Vicci L., Li, Yingming, Dehm, Scott M., Zimmerman, Cheryl L., Niehans, Gloria A., Unger, Gretchen M., Trembley, Janeen H.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308691/
https://ncbi.nlm.nih.gov/pubmed/27557516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11442
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