Generation of TALEN-mediated FH knockout rat model

Transcription activator-like effector nucleases (TALENs) are valuable tools for precise genome engineering of laboratory animals. Here we utilized this technique for efficient site-specific gene modification to create a fumarate hydratase (FH) gene knockout rat model, in which there was an 11 base-p...

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Publicado en:Oncotarget
Autores principales: Yu, Dandan, Zhong, Yali, Li, Xiaoran, Li, Yaqing, Li, Xiaoli, Cao, Jing, Fan, Zhirui, Fan, Huijie, Yuan, Long, Xu, Benling, Yuan, Yuan, Zhang, Hongquan, Ji, Zhenyu, Wen, Jian-Guo, Zhang, Mingzhi, Nesland, Jahn M., Suo, Zhenhe
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308680/
https://ncbi.nlm.nih.gov/pubmed/27556703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11429
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