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Hypoxia-responsive ionizable liposome delivery siRNA for glioma therapy

Here, we report the hypoxia-responsive ionizable liposomes to deliver small interference RNA (siRNA) anticancer drugs, which can selectively enhance cellular uptake of the siRNA under hypoxic and low-pH conditions to cure glioma. For this purpose, malate dehydrogenase lipid molecules were synthesize...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Liu, Hong-Mei, Zhang, Ya-Fei, Xie, Yan-Dong, Cai, Yi-Fan, Li, Bai-Yang, Li, Wen, Zeng, Ling-Yu, Li, Yu-Ling, Yu, Ru-Tong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308568/
https://ncbi.nlm.nih.gov/pubmed/28223799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S125286
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