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Transcriptional Addiction in Cancer

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here we discuss how transcriptional control is disrupted by genetic alteration...

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Bibliographic Details
Published in:Cell
Main Authors: Bradner, James E., Hnisz, Denes, Young, Richard A.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308559/
https://ncbi.nlm.nih.gov/pubmed/28187285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.013
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