Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization()

The natural products colchicine and combretastatin A-4 (CA4) have been inspirational for the design and synthesis of structurally related analogues and spin-off compounds as inhibitors of tubulin polymerization. The discovery that a water-soluble phosphate prodrug salt of CA4 (referred to as CA4P) i...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Herdman, Christine A., Strecker, Tracy E., Tanpure, Rajendra P., Chen, Zhi, Winters, Alex, Gerberich, Jeni, Liu, Li, Hamel, Ernest, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308454/
https://ncbi.nlm.nih.gov/pubmed/28217276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00459H
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