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Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation

Fmoc solid phase peptide synthesis of thioesters for the chemical synthesis of proteins via native chemical ligation is a challenge. We have developed a versatile approach for direct synthesis of peptide thioesters from a solid support utilizing Fmoc chemistry. Peptide thioester synthesis is perform...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Elashal, Hader E., Sim, Yonnette E., Raj, Monika
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308276/
https://ncbi.nlm.nih.gov/pubmed/28451155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02162j
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