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Serine promoted synthesis of peptide thioester-precursor on solid support for native chemical ligation

Fmoc solid phase peptide synthesis of thioesters for the chemical synthesis of proteins via native chemical ligation is a challenge. We have developed a versatile approach for direct synthesis of peptide thioesters from a solid support utilizing Fmoc chemistry. Peptide thioester synthesis is perform...

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Pubblicato in:Chem Sci
Autori principali: Elashal, Hader E., Sim, Yonnette E., Raj, Monika
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308276/
https://ncbi.nlm.nih.gov/pubmed/28451155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02162j
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