Chiral resolution of serial potent and selective σ(1) ligands and biological evaluation of (−)-[(18)F]TZ3108 in rodent and the nonhuman primate brain

Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ(1)) receptor ligands. The in vitro binding affinities of each enantiomer for σ(1), σ(2) receptors and vesicu...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Yue, Xuyi, Jin, Hongjun, Luo, Zonghua, Liu, Hui, Zhang, Xiang, McSpadden, Ethan D., Tian, Linlin, Flores, Hubert P., Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303003/
https://ncbi.nlm.nih.gov/pubmed/28129990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.017
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados