Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was to compare two potent and selective PDE10A ra...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Liu, Hui, Jin, Hongjun, Yue, Xuyi, Han, Junbin, Yang, Hao, Flores, Hubert, Su, Yi, Alagille, David, Perlmutter, Joel S., Tamagnan, Gilles, Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5045939/
https://ncbi.nlm.nih.gov/pubmed/27713824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.253
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