Chiral resolution of serial potent and selective σ(1) ligands and biological evaluation of (−)-[(18)F]TZ3108 in rodent and the nonhuman primate brain

Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ(1)) receptor ligands. The in vitro binding affinities of each enantiomer for σ(1), σ(2) receptors and vesicu...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem
Asıl Yazarlar: Yue, Xuyi, Jin, Hongjun, Luo, Zonghua, Liu, Hui, Zhang, Xiang, McSpadden, Ethan D., Tian, Linlin, Flores, Hubert P., Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303003/
https://ncbi.nlm.nih.gov/pubmed/28129990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.017
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