Chiral resolution of serial potent and selective σ(1) ligands and biological evaluation of (−)-[(18)F]TZ3108 in rodent and the nonhuman primate brain

Twelve optically pure enantiomers were obtained using either crystallization or chiral high performance liquid chromatography (HPLC) separation methodologies to resolve six racemic sigma-1 (σ(1)) receptor ligands. The in vitro binding affinities of each enantiomer for σ(1), σ(2) receptors and vesicu...

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Publicat a:Bioorg Med Chem
Autors principals: Yue, Xuyi, Jin, Hongjun, Luo, Zonghua, Liu, Hui, Zhang, Xiang, McSpadden, Ethan D., Tian, Linlin, Flores, Hubert P., Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303003/
https://ncbi.nlm.nih.gov/pubmed/28129990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.017
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