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The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

Here, we found that both SAHA and MG132 synergistically inhibited proliferation, glycolysis and mitochondrial oxidization, induced cell cycle arrest and apoptosis in MGC-803 and MKN28 cells. SAHA increased cell migration and invasionat a low concentration. SAHA induced the overexpression of acetyl h...

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محفوظ في:

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Oncotarget
المؤلفون الرئيسيون:	Lu, Hang, Yang, Xue-feng, Tian, Xiao-qing, Tang, Shou-long, Li, Lian-qian, Zhao, Shuang, Zheng, Hua-chuan
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Impact Journals LLC 2016
الموضوعات:	Research Paper
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5302865/ https://ncbi.nlm.nih.gov/pubmed/27447743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10643
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The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

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