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In Vivo PET-imaging of Histone Deacetylases by 18F-Suberoylanilide Hydroxamic Acid ((18)F-SAHA)()
Histone deacetylases (HDACs) are a group of enzymes that modulate gene expression and cell state by deacetylation of both histone and non-histone proteins. A variety of HDAC inhibitors (HDACi) have already undergone clinical testing in cancer. Real-time in vivo imaging of HDACs and their inhibition...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150598/ https://ncbi.nlm.nih.gov/pubmed/21721525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200620f |
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