The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

Here, we found that both SAHA and MG132 synergistically inhibited proliferation, glycolysis and mitochondrial oxidization, induced cell cycle arrest and apoptosis in MGC-803 and MKN28 cells. SAHA increased cell migration and invasionat a low concentration. SAHA induced the overexpression of acetyl h...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lu, Hang, Yang, Xue-feng, Tian, Xiao-qing, Tang, Shou-long, Li, Lian-qian, Zhao, Shuang, Zheng, Hua-chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302865/
https://ncbi.nlm.nih.gov/pubmed/27447743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10643
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