CREBBP inactivation promotes the development of HDAC3 dependent lymphomas

Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates development of germinal center derived lymphomas in mice. In both human and murine lymphomas CREBBP loss of function resulted in focal depletion of enhancer H3K27 acetylation and aberrant t...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Jiang, Yanwen, Ortega-Molina, Ana, Geng, Huimin, Ying, Hsia-Yuan, Hatzi, Katerina, Parsa, Sara, McNally, Dylan, Wang, Ling, Doane, Ashley S., Ena, Xabier Agirre, Teater, Matt, Meydan, Cem, Li, Zhuoning, Poloway, David, Wang, Shenqiu, Ennishi, Daisuke, Scott, David W., Stengel, Kristy R., Kranz, Janice E., Holson, Edward, Sharma, Sneh, Young, James W., Chu, Chi-Shuen, Roeder, Robert G., Shaknovich, Rita, Hiebert, Scott W., Gascoyne, Randy D., Tam, Wayne, Elemento, Olivier, Wendel, Hans-Guido, Melnick, Ari M.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300005/
https://ncbi.nlm.nih.gov/pubmed/27733359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0975
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