CREBBP inactivation promotes the development of HDAC3 dependent lymphomas

Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss of CREBBP facilitates development of germinal center derived lymphomas in mice. In both human and murine lymphomas CREBBP loss of function resulted in focal depletion of enhancer H3K27 acetylation and aberrant t...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Jiang, Yanwen, Ortega-Molina, Ana, Geng, Huimin, Ying, Hsia-Yuan, Hatzi, Katerina, Parsa, Sara, McNally, Dylan, Wang, Ling, Doane, Ashley S., Ena, Xabier Agirre, Teater, Matt, Meydan, Cem, Li, Zhuoning, Poloway, David, Wang, Shenqiu, Ennishi, Daisuke, Scott, David W., Stengel, Kristy R., Kranz, Janice E., Holson, Edward, Sharma, Sneh, Young, James W., Chu, Chi-Shuen, Roeder, Robert G., Shaknovich, Rita, Hiebert, Scott W., Gascoyne, Randy D., Tam, Wayne, Elemento, Olivier, Wendel, Hans-Guido, Melnick, Ari M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300005/
https://ncbi.nlm.nih.gov/pubmed/27733359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0975
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