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Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

This phase 1 trial evaluated pharmacokinetic and pharmacodynamic interactions between the novel triazole antifungal agent isavuconazole and warfarin in healthy adults. Multiple doses of isavuconazole were administered as the oral prodrug, isavuconazonium sulfate (372 mg 3 times a day for 2 days load...

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Bibliografske podrobnosti
izdano v:Clin Pharmacol Drug Dev
Main Authors: Desai, Amit, Yamazaki, Takao, Dietz, Albert J., Kowalski, Donna, Lademacher, Christopher, Pearlman, Helene, Akhtar, Shahzad, Townsend, Robert
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298089/
https://ncbi.nlm.nih.gov/pubmed/27278712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.283
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