Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

This phase 1 trial evaluated pharmacokinetic and pharmacodynamic interactions between the novel triazole antifungal agent isavuconazole and warfarin in healthy adults. Multiple doses of isavuconazole were administered as the oral prodrug, isavuconazonium sulfate (372 mg 3 times a day for 2 days load...

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Veröffentlicht in:Clin Pharmacol Drug Dev
Hauptverfasser: Desai, Amit, Yamazaki, Takao, Dietz, Albert J., Kowalski, Donna, Lademacher, Christopher, Pearlman, Helene, Akhtar, Shahzad, Townsend, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298089/
https://ncbi.nlm.nih.gov/pubmed/27278712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.283
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