Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects

This article summarizes 4 phase 1 trials that explored interactions between the novel, triazole antifungal isavuconazole and substrates of the drug transporters breast cancer resistance protein (BCRP), multidrug and toxin extrusion protein‐1 (MATE1), organic anion transporters 1/3 (OAT1/OAT3), organ...

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Pubblicato in:Clin Pharmacol Drug Dev
Autori principali: Yamazaki, Takao, Desai, Amit, Goldwater, Ronald, Han, David, Lasseter, Kenneth C., Howieson, Corrie, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Rammelsberg, Diane, Townsend, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297980/
https://ncbi.nlm.nih.gov/pubmed/27273004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.280
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