Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

This report describes the phase 1 trials that evaluated the metabolism of the novel triazole antifungal isavuconazole by cytochrome P450 3A4 (CYP3A4) and isavuconazole's effects on CYP3A4‐mediated metabolism in healthy adults. Coadministration of oral isavuconazole (100 mg once daily) with oral...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Drug Dev
Main Authors: Townsend, Robert, Dietz, Albert, Hale, Christine, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Lasseter, Kenneth, Pearlman, Helene, Rammelsberg, Diane, Schmitt‐Hoffmann, Anne, Yamazaki, Takao, Desai, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5298035/
https://ncbi.nlm.nih.gov/pubmed/27273461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.285
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