Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong inhibitors of JAKs and can play pivotal roles...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Jiang, Mengmeng, Zhang, Wen-wen, Liu, Pengpeng, Yu, Wenwen, Liu, Ting, Yu, Jinpu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296614/
https://ncbi.nlm.nih.gov/pubmed/28228755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00070
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