Interleukin-6 Trans-Signaling Pathway Promotes Immunosuppressive Myeloid-Derived Suppressor Cells via Suppression of Suppressor of Cytokine Signaling 3 in Breast Cancer

Interleukin-6 (IL-6) has been reported to stimulate myeloid-derived suppressor cells (MDSCs) in multiple cancers, but the molecular events involved in this process are not completely understood. We previously found that cancer-derived IL-6 induces T cell suppression of MDSCs in vitro via the activat...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Jiang, Mengmeng, Chen, Jieying, Zhang, Wenwen, Zhang, Rui, Ye, Yingnan, Liu, Pengpeng, Yu, Wenwen, Wei, Feng, Ren, Xiubao, Yu, Jinpu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736866/
https://ncbi.nlm.nih.gov/pubmed/29326716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01840
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