Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong inhibitors of JAKs and can play pivotal roles...

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Detaylı Bibliyografya
Yayımlandı:Front Immunol
Asıl Yazarlar: Jiang, Mengmeng, Zhang, Wen-wen, Liu, Pengpeng, Yu, Wenwen, Liu, Ting, Yu, Jinpu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2017
Konular:
Immunology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296614/
https://ncbi.nlm.nih.gov/pubmed/28228755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00070
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