Imbalance between HDAC and HAT activities drives aberrant STAT1/MyD88 expression in macrophages from type 1 diabetic mice

AIMS: To investigate the hypothesis that alteration in histone acetylation/deacetylation triggers aberrant STAT1/MyD88 expression in macrophages from diabetics. Increased STAT1/MyD88 expression is correlated with sterile inflammation in type 1 diabetic (T1D) mice. METHODS: To induce diabetes, we inj...

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Detalhes bibliográficos
Publicado no:J Diabetes Complications
Main Authors: Filgueiras, Luciano Ribeiro, Brandt, Stephanie L., de Oliveira Ramalho, Theresa Raquel, Jancar, Sonia, Serezani, C. Henrique
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296405/
https://ncbi.nlm.nih.gov/pubmed/27623388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jdiacomp.2016.08.001
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