Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis

Sepsis-induced organ damage is caused by systemic inflammatory response syndrome (SIRS), which results in substantial comorbidities. Therefore, it is of medical importance to identify molecular brakes that can be exploited to dampen inflammation and prevent SIRS development. The current study invest...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Sisti, Flavia, Wang, Soujuan, Brandt, Stephanie L., Glosson-Byers, Nicole, Mayo, Lindsey, Son, Young min, Sturgeon, Sarah, Filgueiras, Luciano, Jancar, Sonia, Wong, Hector, Dela Cruz, Charles S., Andrews, Nathaniel, Alves-Filho, Jose Carlos, Cunha, Fernando Q., Serezani, C. Henrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147521/
https://ncbi.nlm.nih.gov/pubmed/29717063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aai9085
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