PPAR-γ/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis

Polymicrobial sepsis induces organ failure and is accompanied by overwhelming inflammatory response and impairment of microbial killing. Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a nuclear receptor with pleiotropic effects on lipid metabolism, inflammation, and cell proliferation....

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Autori principali: Ferreira, Ana Elisa, Sisti, Flavia, Sônego, Fabiane, Wang, Suojang, Filgueiras, Luciano, Brandt, Stephanie, Serezani, Ana Paula Moreira, Du, Hong, Cunha, Fernando Q., Alves-Filho, Jose Carlos, Serezani, Carlos Henrique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943997/
https://ncbi.nlm.nih.gov/pubmed/24489087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302375
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