MyD88-, but Not Nod1- and/or Nod2-Deficient Mice, Show Increased Susceptibility to Polymicrobial Sepsis due to Impaired Local Inflammatory Response

Pathogen recognition and triggering of the inflammatory response following infection in mammals depend mainly on Toll-like and Nod-like receptors. Here, we evaluated the role of Nod1, Nod2 and MyD88-dependent signaling in the chemokine production and neutrophil recruitment to the infectious site dur...

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Detalhes bibliográficos
Main Authors: Sônego, Fabiane, Castanheira, Fernanda V. S., Czaikoski, Paula G., Kanashiro, Alexandre, Souto, Fabricio O., França, Rafael O., Nascimento, Daniele C., Freitas, Andressa, Spiller, Fernando, Cunha, Larissa D., Zamboni, Dario S., Alves-Filho, José C., Cunha, Fernando Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118952/
https://ncbi.nlm.nih.gov/pubmed/25084278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103734
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