Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates

BACKGROUND: Transplantation of genetically modified bone marrow concentrates is an attractive approach to conveniently activate the chondrogenic differentiation processes as a means to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: Human bone marrow aspirates were c...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Orthop
Auteurs principaux: Tao, Ke, Rey-Rico, Ana, Frisch, Janina, Venkatesan, Jagadeesh Kumar, Schmitt, Gertrud, Madry, Henning, Lin, Jianhao, Cucchiarini, Magali
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2017
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296264/
https://ncbi.nlm.nih.gov/pubmed/28176272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40634-017-0077-5
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