Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

BACKGROUND: Articular cartilage has a limited potential for self-healing. Transplantation of genetically modified progenitor cells like bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the intrinsic repair capacities of damaged articular cartilage. METHODS: In t...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Tao, Ke, Frisch, Janina, Rey-Rico, Ana, Venkatesan, Jagadeesh K., Schmitt, Gertrud, Madry, Henning, Lin, Jianhao, Cucchiarini, Magali
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4736112/
https://ncbi.nlm.nih.gov/pubmed/26830674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0280-9
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