TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2

BACKGROUND: Glioblastoma is the most malignant tumor of the central nervous system and still lacks effective treatment. This study explores mutational biomarkers of 11 drugs targeting either the RTK/Ras/PI3K, the p53 or the Rb pathway using 25 patient-derived glioblastoma stem-like cell cultures (GS...

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Publicado en:Oncotarget
Autores principales: Venkatesan, Subramanian, Hoogstraat, Marlous, Caljouw, Ester, Pierson, Tessa, Spoor, Jochem K.H., Zeneyedpour, Lona, Dubbink, Hendrikus J., Dekker, Lennard J., van der Kaaij, Mariëlle, Kloezeman, Jenneke, Berghauser Pont, Lotte M.E., Besselink, Nicolle J.M., Luider, Theo M., Joore, Jos, Martens, John W., Lamfers, Martine L.M., Sleijfer, Stefan, Leenstra, Sieger
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5295441/
https://ncbi.nlm.nih.gov/pubmed/27533080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11205
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