Prion replication without host adaptation during interspecies transmissions

Adaptation of prions to new species is thought to reflect the capacity of the host-encoded cellular form of the prion protein (PrP(C)) to selectively propagate optimized prion conformations from larger ensembles generated in the species of origin. Here we describe an alternate replicative process, t...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bian, Jifeng, Khaychuk, Vadim, Angers, Rachel C., Fernández-Borges, Natalia, Vidal, Enric, Meyerett-Reid, Crystal, Kim, Sehun, Calvi, Carla L., Bartz, Jason C., Hoover, Edward A., Agrimi, Umberto, Richt, Jürgen A., Castilla, Joaquín, Telling, Glenn C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293081/
https://ncbi.nlm.nih.gov/pubmed/28096357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611891114
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