Prion replication without host adaptation during interspecies transmissions

Adaptation of prions to new species is thought to reflect the capacity of the host-encoded cellular form of the prion protein (PrP(C)) to selectively propagate optimized prion conformations from larger ensembles generated in the species of origin. Here we describe an alternate replicative process, t...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bian, Jifeng, Khaychuk, Vadim, Angers, Rachel C., Fernández-Borges, Natalia, Vidal, Enric, Meyerett-Reid, Crystal, Kim, Sehun, Calvi, Carla L., Bartz, Jason C., Hoover, Edward A., Agrimi, Umberto, Richt, Jürgen A., Castilla, Joaquín, Telling, Glenn C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293081/
https://ncbi.nlm.nih.gov/pubmed/28096357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611891114
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