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Towards the development of activity-based probes for detection of Lysine-Specific Demethylase-1 activity

The implications of Lysine-Specific Demethylase-1 (LSD1) in tumorigenesis have urged scientists to develop diagnostic tools in order to explore the function of this enzyme. In this work, we present our efforts on the development of tranylcypromine (TCP)-based functionalized probes for activity-based...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Ourailidou, Maria E., Lenoci, Alessia, Zwergel, Clemens, Rotili, Dante, Mai, Antonello, Dekker, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5292237/
https://ncbi.nlm.nih.gov/pubmed/27989416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.11.043
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