Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening followed by chemical optimization. HCV-371 displayed broad...

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Autors principals: Howe, Anita Y. M., Bloom, Johnathan, Baldick, Carl J., Benetatos, Christopher A., Cheng, Huiming, Christensen, Joel S., Chunduru, Srinivas K., Coburn, Glen A., Feld, Boris, Gopalsamy, Ariamala, Gorczyca, William P., Herrmann, Steve, Johann, Stephen, Jiang, Xiaoqun, Kimberland, Michelle L., Krisnamurthy, Girija, Olson, Matthew, Orlowski, Mark, Swanberg, Steve, Thompson, Ian, Thorn, Megan, Del Vecchio, Alfred, Young, Dorothy C., van Zeijl, Marja, Ellingboe, John W., Upeslacis, Janis, Collett, Marc, Mansour, Tarek S., O'Connell, John F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC529219/
https://ncbi.nlm.nih.gov/pubmed/15561861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4813-4821.2004
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