Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening followed by chemical optimization. HCV-371 displayed broad...

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Detalles Bibliográficos
Main Authors: Howe, Anita Y. M., Bloom, Johnathan, Baldick, Carl J., Benetatos, Christopher A., Cheng, Huiming, Christensen, Joel S., Chunduru, Srinivas K., Coburn, Glen A., Feld, Boris, Gopalsamy, Ariamala, Gorczyca, William P., Herrmann, Steve, Johann, Stephen, Jiang, Xiaoqun, Kimberland, Michelle L., Krisnamurthy, Girija, Olson, Matthew, Orlowski, Mark, Swanberg, Steve, Thompson, Ian, Thorn, Megan, Del Vecchio, Alfred, Young, Dorothy C., van Zeijl, Marja, Ellingboe, John W., Upeslacis, Janis, Collett, Marc, Mansour, Tarek S., O'Connell, John F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC529219/
https://ncbi.nlm.nih.gov/pubmed/15561861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4813-4821.2004
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