Novel Nonnucleoside Inhibitor of Hepatitis C Virus RNA-Dependent RNA Polymerase

A novel nonnucleoside inhibitor of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), [(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyano[3,4-b]indol-1-yl] acetic acid (HCV-371), was discovered through high-throughput screening followed by chemical optimization. HCV-371 displayed broad...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Howe, Anita Y. M., Bloom, Johnathan, Baldick, Carl J., Benetatos, Christopher A., Cheng, Huiming, Christensen, Joel S., Chunduru, Srinivas K., Coburn, Glen A., Feld, Boris, Gopalsamy, Ariamala, Gorczyca, William P., Herrmann, Steve, Johann, Stephen, Jiang, Xiaoqun, Kimberland, Michelle L., Krisnamurthy, Girija, Olson, Matthew, Orlowski, Mark, Swanberg, Steve, Thompson, Ian, Thorn, Megan, Del Vecchio, Alfred, Young, Dorothy C., van Zeijl, Marja, Ellingboe, John W., Upeslacis, Janis, Collett, Marc, Mansour, Tarek S., O'Connell, John F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC529219/
https://ncbi.nlm.nih.gov/pubmed/15561861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4813-4821.2004
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki