Analysis with the exome array identifies multiple new independent variants in lipid loci

It has been hypothesized that low frequency (1–5% minor allele frequency (MAF)) and rare (<1% MAF) variants with large effect sizes may contribute to the missing heritability in complex traits. Here, we report an association analysis of lipid traits (total cholesterol, LDL-cholesterol, HDL-choles...

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出版年:Hum Mol Genet
主要な著者: Kanoni, Stavroula, Masca, Nicholas G.D., Stirrups, Kathleen E., Varga, Tibor V., Warren, Helen R., Scott, Robert A., Southam, Lorraine, Zhang, Weihua, Yaghootkar, Hanieh, Müller-Nurasyid, Martina, Couto Alves, Alexessander, Strawbridge, Rona J., Lataniotis, Lazaros, An Hashim, Nikman, Besse, Céline, Boland, Anne, Braund, Peter S., Connell, John M., Dominiczak, Anna, Farmaki, Aliki-Eleni, Franks, Stephen, Grallert, Harald, Jansson, Jan-Håkan, Karaleftheri, Maria, Keinänen-Kiukaanniemi, Sirkka, Matchan, Angela, Pasko, Dorota, Peters, Annette, Poulter, Neil, Rayner, Nigel W., Renström, Frida, Rolandsson, Olov, Sabater-Lleal, Maria, Sennblad, Bengt, Sever, Peter, Shields, Denis, Silveira, Angela, Stanton, Alice V., Strauch, Konstantin, Tomaszewski, Maciej, Tsafantakis, Emmanouil, Waldenberger, Melanie, Blakemore, Alexandra I.F., Dedoussis, George, Escher, Stefan A., Kooner, Jaspal S., McCarthy, Mark I., Palmer, Colin N.A., Hamsten, Anders, Caulfield, Mark J., Frayling, Timothy M., Tobin, Martin D., Jarvelin, Marjo-Riitta, Zeggini, Eleftheria, Gieger, Christian, Chambers, John C., Wareham, Nick J., Munroe, Patricia B., Franks, Paul W., Samani, Nilesh J., Deloukas, Panos
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2016
主題:
Association Studies Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291227/
https://ncbi.nlm.nih.gov/pubmed/27466198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw227
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