Signal Integration at Elongation Factor 2 Kinase: THE ROLES OF CALCIUM, CALMODULIN, AND SER-500 PHOSPHORYLATION

Eukaryotic elongation factor 2 kinase (eEF-2K), the only calmodulin (CaM)-dependent member of the unique α-kinase family, impedes protein synthesis by phosphorylating eEF-2. We recently identified Thr-348 and Ser-500 as two key autophosphorylation sites within eEF-2K that regulate its activity. eEF-...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Tavares, Clint D. J., Giles, David H., Stancu, Gabriel, Chitjian, Catrina A., Ferguson, Scarlett B., Wellmann, Rebecca M., Kaoud, Tamer S., Ghose, Ranajeet, Dalby, Kevin N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290972/
https://ncbi.nlm.nih.gov/pubmed/27956550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753277
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