Assessing Oxidative Stress in Tumors by Measuring the Rate of Hyperpolarized [1-(13)C]Dehydroascorbic Acid Reduction Using (13)C Magnetic Resonance Spectroscopy

Rapid cancer cell proliferation promotes the production of reducing equivalents, which counteract the effects of relatively high levels of reactive oxygen species. Reactive oxygen species levels increase in response to chemotherapy and cell death, whereas an increase in antioxidant capacity can conf...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Timm, Kerstin N., Hu, De-En, Williams, Michael, Wright, Alan J., Kettunen, Mikko I., Kennedy, Brett W. C., Larkin, Timothy J., Dzien, Piotr, Marco-Rius, Irene, Bohndiek, Sarah E., Brindle, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290948/
https://ncbi.nlm.nih.gov/pubmed/27994059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.761536
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