(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

PURPOSE: Dissolution dynamic nuclear polarization can increase the sensitivity of the (13)C magnetic resonance spectroscopy experiment by at least four orders of magnitude and offers a novel approach to the development of MRI gene reporters based on enzymes that metabolize (13)C‐labeled tracers. We...

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Publicado no:Magn Reson Med
Main Authors: Dzien, Piotr, Tee, Sui‐Seng, Kettunen, Mikko I., Lyons, Scott K., Larkin, Timothy J., Timm, Kerstin N., Hu, De‐En, Wright, Alan, Rodrigues, Tiago B., Serrao, Eva M., Marco‐Rius, Irene, Mannion, Elizabeth, D'Santos, Paula, Kennedy, Brett W. C., Brindle, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Preclinical and Clinical Spectroscopy—Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025726/
https://ncbi.nlm.nih.gov/pubmed/26388418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.25879
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