(13)C magnetic resonance spectroscopy measurements with hyperpolarized [1‐(13)C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

PURPOSE: Dissolution dynamic nuclear polarization can increase the sensitivity of the (13)C magnetic resonance spectroscopy experiment by at least four orders of magnitude and offers a novel approach to the development of MRI gene reporters based on enzymes that metabolize (13)C‐labeled tracers. We...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Magn Reson Med
Prif Awduron: Dzien, Piotr, Tee, Sui‐Seng, Kettunen, Mikko I., Lyons, Scott K., Larkin, Timothy J., Timm, Kerstin N., Hu, De‐En, Wright, Alan, Rodrigues, Tiago B., Serrao, Eva M., Marco‐Rius, Irene, Mannion, Elizabeth, D'Santos, Paula, Kennedy, Brett W. C., Brindle, Kevin M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2015
Pynciau:
Preclinical and Clinical Spectroscopy—Full Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025726/
https://ncbi.nlm.nih.gov/pubmed/26388418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mrm.25879
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