Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

Synucleinophaties are progressive neurodegenerative disorders with no cure to date. An attractive strategy to tackle this problem is repurposing already tested safe drugs against novel targets. In this way, doxycycline prevents neurodegeneration in Parkinson models by modulating neuroinflammation. H...

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Publicado no:Sci Rep
Main Authors: González-Lizárraga, Florencia, Socías, Sergio B., Ávila, César L., Torres-Bugeau, Clarisa M., Barbosa, Leandro R. S., Binolfi, Andres, Sepúlveda-Díaz, Julia E., Del-Bel, Elaine, Fernandez, Claudio O., Papy-Garcia, Dulce, Itri, Rosangela, Raisman-Vozari, Rita, Chehín, Rosana N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290535/
https://ncbi.nlm.nih.gov/pubmed/28155912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41755
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