Structural Characterization of Heparin-induced Glyceraldehyde-3-phosphate Dehydrogenase Protofibrils Preventing α-Synuclein Oligomeric Species Toxicity

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that has been associated with neurodegenerative diseases. GAPDH colocalizes with α-synuclein in amyloid aggregates in post-mortem tissue of patients with sporadic Parkinson disease and promotes the formation of Lewy body-li...

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Autori principali: Ávila, César L., Torres-Bugeau, Clarisa M., Barbosa, Leandro R. S., Sales, Elisa Morandé, Ouidja, Mohand O., Socías, Sergio B., Celej, M. Soledad, Raisman-Vozari, Rita, Papy-Garcia, Dulce, Itri, Rosangela, Chehín, Rosana N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022857/
https://ncbi.nlm.nih.gov/pubmed/24671416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544288
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