Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates

Aggregated forms of the synaptic protein α-synuclein (αS) have been proposed to operate as a molecular trigger for microglial inflammatory processes and neurodegeneration in Parkinson´s disease. Here, we used brain microglial cell cultures activated by fibrillary forms of recombinant human αS to ass...

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Veröffentlicht in:Cells
Hauptverfasser: Acuña, Leonardo, Hamadat, Sabah, Corbalán, Natalia S., González-Lizárraga, Florencia, dos-Santos-Pereira, Mauricio, Rocca, Jérémy, Sepúlveda Díaz, Julia, Del-Bel, Elaine, Papy-García, Dulce, Chehín, Rosana N., Michel, Patrick P., Raisman-Vozari, Rita
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721546/
https://ncbi.nlm.nih.gov/pubmed/31349736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080776
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