Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11 gene encoding BSEP induces BSEP deficiency and progressive familial intrahepatic cholestasis type 2 (PFIC2). Because live...

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Publicat a:Sci Rep
Autors principals: Imagawa, Kazuo, Takayama, Kazuo, Isoyama, Shigemi, Tanikawa, Ken, Shinkai, Masato, Harada, Kazuo, Tachibana, Masashi, Sakurai, Fuminori, Noguchi, Emiko, Hirata, Kazumasa, Kage, Masayoshi, Kawabata, Kenji, Sumazaki, Ryo, Mizuguchi, Hiroyuki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288783/
https://ncbi.nlm.nih.gov/pubmed/28150711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41806
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