Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

Interindividual differences in hepatic metabolism, which are mainly due to genetic polymorphism in its gene, have a large influence on individual drug efficacy and adverse reaction. Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem (iPS) cells have the potential to pred...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Takayama, Kazuo, Morisaki, Yuta, Kuno, Shuichi, Nagamoto, Yasuhito, Harada, Kazuo, Furukawa, Norihisa, Ohtaka, Manami, Nishimura, Ken, Imagawa, Kazuo, Sakurai, Fuminori, Tachibana, Masashi, Sumazaki, Ryo, Noguchi, Emiko, Nakanishi, Mahito, Hirata, Kazumasa, Kawabata, Kenji, Mizuguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250156/
https://ncbi.nlm.nih.gov/pubmed/25385620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413481111
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