Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling

The function of hepatocytes largely depends on their position in the liver lobule. Although the method of differentiating hepatocytes from human pluripotent stem cells has been largely improved over the past decade, there remains no technique for generating hepatocyte-like cells (HLCs) with zone-spe...

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Vydáno v:Mol Ther
Hlavní autoři: Mitani, Seiji, Takayama, Kazuo, Nagamoto, Yasuhito, Imagawa, Kazuo, Sakurai, Fuminori, Tachibana, Masashi, Sumazaki, Ryo, Mizuguchi, Hiroyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475257/
https://ncbi.nlm.nih.gov/pubmed/28462819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.04.006
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