Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11 gene encoding BSEP induces BSEP deficiency and progressive familial intrahepatic cholestasis type 2 (PFIC2). Because live...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Imagawa, Kazuo, Takayama, Kazuo, Isoyama, Shigemi, Tanikawa, Ken, Shinkai, Masato, Harada, Kazuo, Tachibana, Masashi, Sakurai, Fuminori, Noguchi, Emiko, Hirata, Kazumasa, Kage, Masayoshi, Kawabata, Kenji, Sumazaki, Ryo, Mizuguchi, Hiroyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288783/
https://ncbi.nlm.nih.gov/pubmed/28150711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41806
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