Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11 gene encoding BSEP induces BSEP deficiency and progressive familial intrahepatic cholestasis type 2 (PFIC2). Because live...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Imagawa, Kazuo, Takayama, Kazuo, Isoyama, Shigemi, Tanikawa, Ken, Shinkai, Masato, Harada, Kazuo, Tachibana, Masashi, Sakurai, Fuminori, Noguchi, Emiko, Hirata, Kazumasa, Kage, Masayoshi, Kawabata, Kenji, Sumazaki, Ryo, Mizuguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288783/
https://ncbi.nlm.nih.gov/pubmed/28150711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41806
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados