(11)C-ER176, a Radioligand for 18-kDa Translocator Protein, Has Adequate Sensitivity to Robustly Image All Three Affinity Genotypes in Human Brain

For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation, most second-generation radioligands are sensitive to the single nucleotide polymorphism rs6971; however, this is probably not the case for the prototypical agent (11)C-PK11195 ((11)C-labeled N-butan-2-yl-1-(2-ch...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Ikawa, Masamichi, Lohith, Talakad G., Shrestha, Stal, Telu, Sanjay, Zoghbi, Sami S., Castellano, Sabrina, Taliani, Sabrina, Da Settimo, Federico, Fujita, Masahiro, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2017
Assuntos:
Neurology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288742/
https://ncbi.nlm.nih.gov/pubmed/27856631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.178996
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