Comparison of four (11)C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. (11)C-(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility of four (11)C-labeled ligands—(R)-PK11195, PBR28, DPA-713, and ER176—to quantify TSPO in healthy humans. For all of these li...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Fujita, Masahiro, Kobayashi, Masato, Ikawa, Masamichi, Gunn, Roger N., Rabiner, Eugenii A., Owen, David R., Zoghbi, Sami S., Haskali, Mohamad B., Telu, Sanjay, Pike, Victor W., Innis, Robert B.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2017
Assuntos:
Commentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643834/
https://ncbi.nlm.nih.gov/pubmed/29038960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-017-0334-8
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