Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety

Oxidative stress is known to play an important role in oral cancer development. In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have chemopreventive effects on oxidative stress-associated oral carcinogenesis. We first showed that Nrf2 activation and ox...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lan, Aixian, Li, Wenjun, Liu, Yao, Xiong, Zhaohui, Zhang, Xinyan, Zhou, Shanshan, Palko, Olesya, Chen, Hao, Kapita, Mayanga, Prigge, Justin R., Schmidt, Edward E., Chen, Xin, Sun, Zheng, Chen, Xiaoxin Luke
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288201/
https://ncbi.nlm.nih.gov/pubmed/27447968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10609
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