Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterically...

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Bibliographic Details
Main Authors: Schiffelers, Raymond M., Ansari, Aslam, Xu, Jun, Zhou, Qin, Tang, Qingquan, Storm, Gert, Molema, Grietje, Lu, Patrick Y., Scaria, Puthupparampil V., Woodle, Martin C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
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NAR Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC528817/
https://ncbi.nlm.nih.gov/pubmed/15520458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gnh140
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