Buffering Capacity and Size of siRNA Polyplexes Influence Cytokine Levels

Induction of cytokines by small interfering RNA (siRNA) polyplexes has been a significant concern of researchers attempting to minimize the toxicity of this promising therapy. Although cationic carriers of siRNA are known to increase cytokine levels, few systematic studies have been done to determin...

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Bibliographic Details
Main Authors: Leng, Qixin, Chou, Szu-Ting, Scaria, Puthupparampil V, Woodle, Martin C, Mixson, A James
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519993/
https://ncbi.nlm.nih.gov/pubmed/23032972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.206
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