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Buffering Capacity and Size of siRNA Polyplexes Influence Cytokine Levels

Induction of cytokines by small interfering RNA (siRNA) polyplexes has been a significant concern of researchers attempting to minimize the toxicity of this promising therapy. Although cationic carriers of siRNA are known to increase cytokine levels, few systematic studies have been done to determin...

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Hlavní autoři: Leng, Qixin, Chou, Szu-Ting, Scaria, Puthupparampil V, Woodle, Martin C, Mixson, A James
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519993/
https://ncbi.nlm.nih.gov/pubmed/23032972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.206
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